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Dr Emanuela Felley-Bosco talks with ecancer at EMCTO 2013 in Lugano, Switzerland about the difficulties of treating mesothelioma. NF2 is the tumour suppressor gene most abundant in mesotheleoma; however there are a number of difficulties in targeting this mutation. Mesothelioma is often associated with exposure to asbestos fibers and leads to continuous tissue damage. Due to the problems in targeting NF2, Dr Felly-Bosco explains how researchers are trying to circumvent this by targeting other stimuli that make the tumour cells to proliferate.